![]() The National Academies Collection: Reports funded by National Institutes of Health. Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D, Calcium. J Bone Miner Res: Off J Am Soc Bone Miner Res. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. KDOQI US commentary on the 2017 KDIGO clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD-MBD). Isakova T, Nickolas TL, Denburg M, Yarlagadda S, Weiner DE, Gutiérrez OM, et al. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D. Pathogenesis of hereditary vitamin-D-dependent rickets. 2013 98:4619–28.įraser D, Kooh SW, Kind HP, Holick MF, Tanaka Y, DeLuca HF. Clinical review: the role of the parent compound vitamin D with respect to metabolism and function: Why clinical dose intervals can affect clinical outcomes. Natural vitamin D content in animal products1. Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens. Minisola S, Cianferotti L, Biondi P, Cipriani C, Fossi C, Franceschelli F, et al. The pharmacology of vitamin D, including fortification strategies. Histomorphometric effects of calcium or calcium plus 25-hydroxyvitamin D3 therapy in senile osteoporosis. Orwoll ES, McClung MR, Oviatt SK, Recker RR, Weigel RM. Effects of calcifediol on calcified tissue in uremia. ![]() Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Monthly high-dose vitamin D treatment for the prevention of functional decline: a randomized clinical trial. 2010 303:1815–22.īischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, et al. Greater seasonal cycling of 25-hydroxyvitamin D is associated with increased parathyroid hormone and bone resorption. 1979 254:12455–60.ĭarling AL, Hart KH, Gibbs MA, Gossiel F, Kantermann T, Horton K, et al. Kinetic behavior of 25-hydroxyvitamin D-1-hydroxylase and -24-hydroxylase in rat kidney mitochondria. How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology. The case against ergocalciferol (vitamin D2) as a vitamin supplement. supplementation with vitamin D2 or D3 on serum 25-hydroxyvitamin D metabolites: an 8-week randomised-controlled trial in young adult Finnish women. Itkonen ST, Skaffari E, Saaristo P, Saarnio EM, Erkkola M, Jakobsen J, et al. Vitamin D supplementation for prevention of mortality in adults. 2012 95:1357–64.ījelakovic G, Gluud LL, Nikolova D, Whitfield K, Wetterslev J, Simonetti RG et al. ![]() Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, et al. Baltimore, MD, USA: Lippincott Williams & Wilkins 2005. Stedman’s Medical Dictionary for the Health Professions and Nursing. Why ‘Vitamin D’ is not a hormone, and not a synonym for 1,25-dihydroxy-vitamin D, its analogs or deltanoids. Therefore, it must be concluded that cholecalciferol is the only form of vitamin D that should be considered in the context of the nutritional functions of fortification and supplementation. Recent evidence shows that ergocalciferol is not stable with storage, and it is far more susceptible to breakdown with cooking and baking than is cholecalciferol. Nutrition policy papers and guidelines leave unstated the obvious fact that calcidiol and calcitriol are not nutrients, and that those metabolites are not pertinent to food fortification or dietary supplementation. Calcidol is the major circulating metabolite of cholecalciferol, while calcitriol is the hormone that upregulates the active transport of calcium from the gut, and which suppresses parathyroid hormone secretion. In contrast, ergocalciferol is primarily a synthetic and less stable product which is less potent per microgram dose than is cholecalciferol. In nature, by far the major form of vitamin D that nurtures the body is cholecalciferol. The term “supplementation” has been used in the context of cholecalciferol, ergocalciferol, calcidiol, and calcitriol. The specific compound that is meant for use in the context of vitamin D supplementation is often ambiguous.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |